GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4820539 | 1 | rs4822360 | chr22:23482460 | RAB36 | chr22:23487513-23506531:+ | 0.18 | 3.57 | 0.00039 | Bone mineral density |
| THCA | cis | rs4820539 | 1 | rs4822361 | chr22:23482718 | GNAZ | chr22:23412669-23467221:+ | 0.22 | 4.73 | 2.98E-6 | Bone mineral density |
| THCA | cis | rs4820539 | 1 | rs4822361 | chr22:23482718 | RAB36 | chr22:23487513-23506531:+ | -0.21 | -4.07 | 5.57E-5 | Bone mineral density |
| THCA | cis | rs4820539 | 1 | rs4822362 | chr22:23482744 | GNAZ | chr22:23412669-23467221:+ | -0.24 | -5.04 | 6.5E-7 | Bone mineral density |
| THCA | cis | rs4820539 | 1 | rs4822362 | chr22:23482744 | RAB36 | chr22:23487513-23506531:+ | 0.2 | 3.87 | 0.000126 | Bone mineral density |
| THCA | cis | rs4823006 | 1 | rs4823006 | chr22:29451671 | C22orf31 | chr22:29454660-29457907:- | 0.21 | 4.37 | 1.52E-5 | Waist-hip ratio |
| THCA | cis | rs1468333 | 1 | rs4835671 | chr5:137511801 | KLHL3 | chr5:136953190-137071779:- | -0.13 | -3.54 | 0.000435 | Resting heart rate |
| THCA | cis | rs1466788 | 1 | rs4838890 | chr1:110616679 | ALX3 | chr1:110602998-110613322:- | -0.3 | -7.48 | 3.67E-13 | Blood metabolite levels |
| THCA | cis | rs1466788 | 1 | rs4839103 | chr1:110620701 | ALX3 | chr1:110602998-110613322:- | -0.3 | -7.52 | 2.81E-13 | Blood metabolite levels |
| THCA | cis | rs1335645 | 1 | rs4839104 | chr1:111708627 | DRAM2 | chr1:111659955-111682838:- | -0.25 | -3.77 | 0.000186 | Liver enzyme levels (gamma-glutamyl transferase) |
| THCA | cis | rs3820443 | 1 | rs4839125 | chr1:111893390 | CHIA | chr1:111833484-111863184:+ | -0.27 | -4.13 | 4.21E-5 | Late-onset Alzheimer's disease |
| THCA | cis | rs3820443 | 1 | rs4839126 | chr1:111893417 | CHIA | chr1:111833484-111863184:+ | -0.27 | -4.13 | 4.21E-5 | Late-onset Alzheimer's disease |
| THCA | cis | rs13256369 | 1 | rs4840351 | chr8:8573148 | SGK223 | chr8:8175259-8239257:- | -0.3 | -5.56 | 4.45E-8 | Obesity-related traits |
| THCA | cis | rs13256369 | 1 | rs4840352 | chr8:8573508 | SGK223 | chr8:8175259-8239257:- | -0.3 | -5.44 | 8.49E-8 | Obesity-related traits |
| THCA | cis | rs13256369 | 1 | rs4841016 | chr8:8572561 | SGK223 | chr8:8175259-8239257:- | -0.3 | -5.44 | 8.49E-8 | Obesity-related traits |